Centromere

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  • a region of a chromosome where it attaches to a spindle fiber during mitosis and meiosis[1]
  • the structure located at a specific site on the chromosome that holds the two chromatids together; it is the site of attachment for the spindle fibers during cell division; also called primary constriction or kinetochore[2]
  • The central portion of the chromosome to which the spindle fibers attach during mitotic and meiotic division.
  • A centromere is a constricted region of a chromosome that separates it into a short arm (p) and a long arm (q). During cell division, the chromosomes first replicate so that each daughter cell receives a complete set of chromosomes. Following DNA replication, the chromosome consists of two identical structures called sister chromatids, which are joined at the centromere.


  1. Source: Noland, George B. 1983. General Biology, 11th Edition. St. Louis, MO. C. V. Mosby
  2. Source: Jenkins, John B. 1990. Human Genetics, 2nd Edition. New York: Harper & Row


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