Gilbert Ashwell (1923-2014) was an American biochemist and cell biologist known for his significant contributions to the understanding of protein metabolism, particularly the receptor-mediated endocytosis of glycoproteins. He was born on October 18, 1923, in Durham, North Carolina, USA.

Key Contributions and Achievements:

1. Receptor-Mediated Endocytosis: Ashwell’s groundbreaking research focused on the process of receptor-mediated endocytosis, a vital cellular mechanism that allows cells to take up specific molecules from their external environment. His work shed light on the role of receptors in recognizing and internalizing glycoproteins.
2. Glycoprotein Research: Ashwell’s studies on glycoproteins were instrumental in understanding their roles in various physiological processes and their implications in diseases.
3. Discovery of Ashwell Receptor: Gilbert Ashwell and his team discovered the Ashwell receptor, which is involved in the clearance of glycoproteins from the blood. This receptor plays a crucial role in regulating glycoprotein levels in circulation.
4. Academic Career: Ashwell served as a faculty member at the National Institutes of Health (NIH) and later became the Chief of the Laboratory of Biochemistry at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
5. Recognition and Awards: Gilbert Ashwell received several prestigious awards and honors for his scientific contributions, including the National Medal of Science and the Gairdner Foundation International Award.
6. Glycobiology: Ashwell’s research significantly advanced the field of glycobiology, which studies the structure, biosynthesis, and functions of carbohydrates and glycoproteins.

Gilbert Ashwell’s work in receptor-mediated endocytosis and glycobiology has had a lasting impact on the field of biochemistry. His discoveries have contributed to our understanding of cellular processes and have implications for various aspects of human health and disease. Ashwell’s dedication to scientific research and his numerous contributions to the field earned him recognition as a prominent figure in biochemistry and cell biology.